Poorly absorbed from the gastrointestinal tract and is excreted almost entirely intestines, and the

Streptomycin sulfate - powder or porous mass of white or almost white, bitter taste. Hygroscopic. Practically insoluble in ethanol, chloroform, ether, easily soluble in water. Thus, the solubility aerospace filtration systems inc (mg / mL) at 28 C: water> 20, 0.85 methanol, ethanol, 0.30, 0.01 isopropanol, 0,015 petroleum ether, carbon

tetrachloride 0.035, 0.035 ether. Stable in weakly acidic medium, is easily destroyed in solutions of strong acids and alkalis on heating. The molecular weight of 1457.39.
Streptomycin sulfate aerospace filtration systems inc used in the / m inside (to influence the intestinal flora), injected into the body cavity. For injection under the lining of the brain in meningitis using only streptomycin-calcium chloride complex (double salt of streptomycin hydrochloride and calcium chloride), which has less irritating than other drugs streptomycin. Toxicity of streptomycin hlorkaltsyevoho large complex, so use it when absolutely aerospace filtration systems inc necessary. Pharmacology.
Penetrates microbial cells by active transport aerospace filtration systems inc and passive diffusion, which is enhanced means, in violation synthesis of cell membranes (eg penicillins). Permanently binds to specific receptor proteins on the 30S subunit of the ribosome. Violated the formation of initiation complex between aerospace filtration systems inc messenger RNA and 30S ribosome subunit. The result is a defect aerospace filtration systems inc when reading the information matrix (information) RNA synthesized defective proteins. Polirybosomy disintegrate and lose their ability to synthesize protein, damaged cytoplasmic membrane and the cell dies.
Streptomycin is active, especially in an alkaline environment against Mycobacterium aerospace filtration systems inc tuberculosis (mainly extracellularly located), the majority of Gram-negative (Escherichia coli, Proteus spp., Enterococcus faecalis, Salmonella

spp., Shigella aerospace filtration systems inc spp., Yersinia spp., Klebsiella spp., In t . including aerospace filtration systems inc Klebsiella pneumoniae, Haemophilus influenzae, Neisseria

gonorhoeae, Neisseria meningitidis,

Brucella spp., Francisella tularensis, Yersinia pestis) and some Gram-positive aerospace filtration systems inc (Staphylococcus aureus, except metitsillinorezistentnyh) microorganisms including strains penitsillinoustoychivye. Less active against aerospace filtration systems inc Streptococcus spp., Including Streptococcus pneumoniae, and Enterobacter spp. Not valid for anaerobes, rickettsiae and viruses. In the treatment of quite rapidly evolving pathogen resistance, and there streptomitsinzavisimye bacteria (mutation receptor protein P12), using streptomycin for its growth. For the treatment of tuberculosis is used only in combination with other anti-TB drugs (except kanamycin and viomitsin). In vitro can form a complex with beta-lactam antibiotics, losing their activity.
Poorly absorbed from the gastrointestinal tract and is excreted almost entirely intestines, and therefore only applies inside intestinal infections, parenteral (V / m) - with the system, aerospace filtration systems inc also used topically. When i / m administration is rapidly and completely absorbed. Quickly absorbed by intrapleural and intraperitoneal administration in large quantities can be absorbed aerospace filtration systems inc during washing voids and cavities (except flushing the bladder). For a single i / m administration at a dose of 1.0 g Cmax is achieved in 1-1.5 hours and is 25-50 mg / ml. Plasma concentration aerospace filtration systems inc decreases slowly (by about 50% over 5-6 hours). Binds to blood proteins is less than 10%. The volume of distribution - 0.2-0.4 l / kg in infants to 0.68 L / kg. Creates high concentrations aerospace filtration systems inc in the kidney (may accumulate in the cortex), lung, liver and extracellular aerospace filtration systems inc fluids (including blood serum, lymph, fluid abscess, the contents of cavities, pleural effusion, ascites, pericardial, peritoneal and synovial fluid). Low concentrations are observed in the bile, watery moisture, sputum and bronchial secretions. It has a mild tropism to muscle, bone and adipose tissue. At therapeutic concentrations through intact blood-brain barrier fails, inflammation of the meninges its permeability to streptomycin increases and the concentration in cerebrospinal fluid is 20% of plasma concentrations. Compared to adults, infants achieved higher its concentration in the cerebrospinal fluid. May cause blockade of neuromuscular aerospace filtration systems inc transmission (curariform action). Metabolism aerospace filtration systems inc can not be. T1 / 2 in adults is 2-4 hours in infants - 5-8 pm In renal failure, depending on the degree of renal dysfunction T1 / 2 can be increased up to 100 h in patients with cystic fibrosis - shortened to 1-2 h excreted in mainly by the kidneys (95%) by glomerular filtration, in small amounts excreted in bile, saliva and sweat. With normal renal function is not kumulyuye. Excreted during hemodialysis (every 4-6 h plasma concentration is reduced by 50%) and to a lesser extent - in the peritoneal